منابع مشابه
Studies on Penicillinase
On alkaline hydrolysis, penicillins are converted into penicilloic acids (1). Penicillinase appears to bring about the same transformation, in which a carboxyl group of pK 4.7 is generated (2). Foster (3) allowed penicillinase to act on penicillin in bicarbonate buffer in the Warburg respirometer and observed the evolution of COZ. Since such a reaction can be followed simply and with considerab...
متن کاملIn Vivo Studies on Staphylococcal Penicillinase.
Eyckmans, Luc (Baylor University Medical Center, Dallas, Tex.), and Ralph Tompsett. In vivo studies on staphylococcal penicillinase. J. Bacteriol. 90:589-593. 1965.-The amounts of staphylococcal penicillinase present in tissue of mice with well-established infections due to penicillin-resistant staphylococci were determined. The data indicate that, in the presence of such infection, penicillina...
متن کاملNew Assay for Penicillinase and Some Results on Penicillinase Induction.
Imsande, John (Western Reserve University, Cleveland, Ohio). New assay for penicillinase and some results on penicillinase induction. J. Bacteriol. 89:1322-1327. 1965.-A rapid, sensitive, and reliable assay of penicillinase activity is described. Studies conducted on the induction of penicillinase, with use of the new assay, show that actinomycin D inhibits growth and the induced synthesis of p...
متن کاملStudies on Penicillinase: III. The Effect of Antipenicillinase on Penicillin-resistant Organisms.
Numerous reports (Carpenter et al., 1944; Spink et al., 1945; Tainter, 1945) have been recorded in the literature describing increased resistance of bacteria to various chemotherapeutic substances, including antibiotics. Increased resistance of organisms to penicillin has been observed (Spink et al., 1945; Tainter, 1945; Demerec, 1945). In the latter case, attempts have been made to control inf...
متن کاملPenicillinase Studies on L-Phase Variants, G-Phase Variants, and Reverted Strains of Staphylococcus aureus.
L-phase variants and small colony (G-phase) variants derived from penicillinase-producing Staphylococcus aureus strains were tested for penicillinase (beta lactamase) production. A refined variation of the modified Gots test for penicillinase was used to demonstrate penicillinase synthesis. Penicillinase synthesis was reduced in L-phase variants and G-phase variants when compared to parental st...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1947
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)31010-4